RapamycinFungusV1, Main, Exploration, bibRecord, 001163

Leucyl-tRNA synthetase: double duty in amino acid sensing.

Identifieur interne : 001163 ( Main/Exploration ); précédent : 001162; suivant : 001164

Leucyl-tRNA synthetase: double duty in amino acid sensing.

Auteurs : Raúl V. Durán [Suisse] ; Michael N. Hall

Source :

Cell research [ 1748-7838 ] ; 2012.

RBID : pubmed:22525334

Descripteurs français

KwdFr :
- Activation enzymatique (MeSH), Animaux (MeSH), Cartographie d'interactions entre protéines (MeSH), Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (métabolisme), Humains (MeSH), Leucine (métabolisme), Leucine-tRNA ligase (métabolisme), Levures (enzymologie), Lysosomes (métabolisme), Mammifères (MeSH), Métabolisme énergétique (MeSH), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH).
MESH :
- enzymologie : Levures.
- métabolisme : Complexes multiprotéiques, Leucine, Leucine-tRNA ligase, Lysosomes, Sérine-thréonine kinases TOR.
- Activation enzymatique, Animaux, Cartographie d'interactions entre protéines, Complexe-1 cible mécanistique de la rapamycine, Humains, Mammifères, Métabolisme énergétique, Transduction du signal.

English descriptors

KwdEn :
- Animals (MeSH), Energy Metabolism (MeSH), Enzyme Activation (MeSH), Humans (MeSH), Leucine (metabolism), Leucine-tRNA Ligase (metabolism), Lysosomes (metabolism), Mammals (MeSH), Mechanistic Target of Rapamycin Complex 1 (MeSH), Multiprotein Complexes (metabolism), Protein Interaction Mapping (MeSH), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism), Yeasts (enzymology).
MESH :
- chemical , metabolism : Leucine, Leucine-tRNA Ligase, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- enzymology : Yeasts.
- metabolism : Lysosomes.
- Animals, Energy Metabolism, Enzyme Activation, Humans, Mammals, Mechanistic Target of Rapamycin Complex 1, Protein Interaction Mapping, Signal Transduction.

Abstract

The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.

DOI: 10.1038/cr.2012.68
PubMed: 22525334
PubMed Central: PMC3411172

Affiliations:

Suisse

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Le document en format XML

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<author><name sortKey="Duran, Raul V" sort="Duran, Raul V" uniqKey="Duran R" first="Raúl V" last="Durán">Raúl V. Durán</name>
<affiliation wicri:level="1"><nlm:affiliation>Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.</nlm:affiliation>
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<author><name sortKey="Hall, Michael N" sort="Hall, Michael N" uniqKey="Hall M" first="Michael N" last="Hall">Michael N. Hall</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Energy Metabolism (MeSH)</term>
<term>Enzyme Activation (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Leucine (metabolism)</term>
<term>Leucine-tRNA Ligase (metabolism)</term>
<term>Lysosomes (metabolism)</term>
<term>Mammals (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Protein Interaction Mapping (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Yeasts (enzymology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Cartographie d'interactions entre protéines (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Leucine (métabolisme)</term>
<term>Leucine-tRNA ligase (métabolisme)</term>
<term>Levures (enzymologie)</term>
<term>Lysosomes (métabolisme)</term>
<term>Mammifères (MeSH)</term>
<term>Métabolisme énergétique (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Leucine</term>
<term>Leucine-tRNA Ligase</term>
<term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Levures</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Yeasts</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lysosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Leucine</term>
<term>Leucine-tRNA ligase</term>
<term>Lysosomes</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Energy Metabolism</term>
<term>Enzyme Activation</term>
<term>Humans</term>
<term>Mammals</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Protein Interaction Mapping</term>
<term>Signal Transduction</term>
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<term>Animaux</term>
<term>Cartographie d'interactions entre protéines</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Humains</term>
<term>Mammifères</term>
<term>Métabolisme énergétique</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.</div>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Leucyl-tRNA synthetase: double duty in amino acid sensing.

Leucyl-tRNA synthetase: double duty in amino acid sensing.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki